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Applications

Environmental Research

Analyses are available for a wide variety of chemicals of environmental interest,

including the following examples:

  • Pesticides, including organochlorine insecticides (e.g., DDX, dieldrin, lindane, chlordane, methoxychlor, toxaphene), herbicides (e.g., glyphosate, atrazine), rodenticides (brodifacoum, diphacinone, difenthialone).
  • Polychlorinated biphenyls (PCBs)
  • Polycyclic aromatic hydrocarbons (PAHs)
  • Metals (e.g., lead, arsenic, cadmium, mercury)
  • Polybrominated flame retardants (PBDEs)
  • Perfluorinated compounds (e.g., PFOA, PFOS)
  • Pharmaceutical and personal care products, (e.g., triclosan, triclocarban), emerging contaminants
  • Metabolites (e.g., hydroxy- metabolites of PAHs, PBDEs, and methoxychlor)

The ATCL specializes in working with biological samples from a variety of species,

including human samples. The laboratory has experience with matrices as varied as

human blood, urine, and breast milk to alligator eggs and bird brains.

 

Additionally, the laboratory is in the process of developing new capabilities for non-

targeted analyses of environmental and biological samples.

 

Endocrine Research

The laboratory offers analysis for most hormones (e.g., E2, EE2, testosterone,

corticosteroids) to support endocrine research projects and the study of endocrine

disrupting substances.

 

Lipidomics

A new AB Sciex QTrap 6500 LCMS was installed at ATCL not only for routine analysis,

but for its specialized capacity to analyze samples for lipidomics. Like proteomics and

metabolomics, lipidomics is a way to see lipids as a constituent of more complex

molecules, and how changes in these organism lipids may affect health and disease.

ATCL has the capability to conduct a global or “shotgun” lipidomics profile of tissues and

cells, as well as targeted analysis of selected lipid classes.

 

Clinical and Pharmaceutical Research

The ATCL has experience conducting analyses to support drug development, including

pharmacokinetic studies measuring parent drug and metabolite(s). The laboratory has

supported biomedical research involving human subjects including analyses of illicit

substances (THC, cocaine, amphetamines, morphine and other opioids), amino acid

panels, uracil, homocysteine, apolipoprotein B-100, DHEA, vitamins, folic acid and folate

cofactors in blood, fatty acids in blood and breast milk, isoflavones in both nutritional and

human prostate cancer studies, antimicrobial agents (chloramphenicol, oxytetracycline,

ticarcillin cefepime), methylphenidate, midazolam and fentanyl trials for new applications

or current drugs, and anabolic steroids in fluids and various tissues.

In addition to research support, the ATCL has conducted stability studies and provided

external validation for pharmaceutical preparations, as well as acted as a resource for

drug diversion and/or abuse testing.