Instrumentation

The ATCL has a variety of analytical instruments available to meet client needs.

Currently available

Agilent 7890/7000C GC-MS/MS. Customized method development for analytical

toxicology screening and quantitative methods is performed on this instrument. We use

this instrument for analysis of organochlorine pesticides (OCPs), polychlorinated

biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs) and other small molecules.

In multiple reaction monitoring (MRM) scan, the system can provide sub-nanogram

quantity of analytes under optimal conditions.

 

ABSCIEX 6500 QTRAP LC-MS/MS, equipped with a Shimadzu LC with the ability to

sample from 96-well plates. This instrument is equipped with a SelexIon system that

helps distinguish isobaric species and reduces matrix effects, thereby increasing signal

to noise ratios. Electrospray ionization (ESI) and Atmospheric Pressure Chemical

Ionization (APCI) can be performed. We use this instrument for analysis of hydroxylated

PAHs, polar pesticides and pesticide metabolites, other small molecules,

pharmaceuticals, and for lipidomics. Signal-to- noise and LOQ is at the pg range over a

wide range of compounds.

 

Agilent MSD HP 5973 GC/MS, equipped with an Agilent GC HP6890. This

instrument is used for fatty acid analysis and for PAHs and other small molecules. In the

standard electron impact selected ion monitoring (SIM) mode, the MSD has sub-

microgram level sensitivity.

 

ThermoFisher Orbitrap LTQ/XL. This instrument is used for targeted and non-targeted

analyses of small molecules. The LTQ Orbitrap XL hybrid mass spectrometer provides

fast, sensitive, and reliable detection and identifications of compounds in complex

mixtures. The outstanding performance characteristics of the LTQ XL include a wide

mass range (m/z 50-2000) and a sensitivity at sub-femtogram level.

 

Thermo MSQ Plus LC/MS. This instrument is used for routine analysis of a variety of

small molecules. When combined with an ion chromatograph front end, it is used to

provide low level quantitation of hard-to- analyze small ionic species such as perchlorate.

 

Agilent HP 1100 HPLC. This HPLC is equipped with various detectors, including UV

and fluorescence, and fraction collector. This system is used for separation of small

molecules and for radiochromatography.

Coming soon …

Leco Pegasus GCxGC TOF MS. This instrument provides four dimensions of analytical

resolution and high full-mass acquisition rates make this instrument well suited for high

throughput analysis of complex mixtures.

Agilent 7900 ICP/MS. This instrument will be used for analysis of major and trace

metals, providing detection down to the sub-parts- per-trillion range.