The ATCL has a variety of analytical instruments available to meet client needs.
Agilent 7890/7000C GC-MS/MS. Customized method development for analytical
toxicology screening and quantitative methods is performed on this instrument. We use
this instrument for analysis of organochlorine pesticides (OCPs), polychlorinated
biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs) and other small molecules.
In multiple reaction monitoring (MRM) scan, the system can provide sub-nanogram
quantity of analytes under optimal conditions.
ABSCIEX 6500 QTRAP LC-MS/MS, equipped with a Shimadzu LC with the ability to
sample from 96-well plates. This instrument is equipped with a SelexIon system that
helps distinguish isobaric species and reduces matrix effects, thereby increasing signal
to noise ratios. Electrospray ionization (ESI) and Atmospheric Pressure Chemical
Ionization (APCI) can be performed. We use this instrument for analysis of hydroxylated
PAHs, polar pesticides and pesticide metabolites, other small molecules,
pharmaceuticals, and for lipidomics. Signal-to- noise and LOQ is at the pg range over a
wide range of compounds.
Agilent MSD HP 5973 GC/MS, equipped with an Agilent GC HP6890. This
instrument is used for fatty acid analysis and for PAHs and other small molecules. In the
standard electron impact selected ion monitoring (SIM) mode, the MSD has sub-
microgram level sensitivity.
ThermoFisher Orbitrap LTQ/XL. This instrument is used for targeted and non-targeted
analyses of small molecules. The LTQ Orbitrap XL hybrid mass spectrometer provides
fast, sensitive, and reliable detection and identifications of compounds in complex
mixtures. The outstanding performance characteristics of the LTQ XL include a wide
mass range (m/z 50-2000) and a sensitivity at sub-femtogram level.
Thermo MSQ Plus LC/MS. This instrument is used for routine analysis of a variety of
small molecules. When combined with an ion chromatograph front end, it is used to
provide low level quantitation of hard-to- analyze small ionic species such as perchlorate.
Agilent HP 1100 HPLC. This HPLC is equipped with various detectors, including UV
and fluorescence, and fraction collector. This system is used for separation of small
molecules and for radiochromatography.
Coming soon …
Leco Pegasus GCxGC TOF MS. This instrument provides four dimensions of analytical
resolution and high full-mass acquisition rates make this instrument well suited for high
throughput analysis of complex mixtures.
Agilent 7900 ICP/MS. This instrument will be used for analysis of major and trace
metals, providing detection down to the sub-parts- per-trillion range.