Dr. Nancy Denslow was successful in acquiring a SIG award from NIH for a new QTRAP 7500+ LC MS/MS instrument with a Core Exion ultra-high pressure liquid chromatography (uHPLC) interface. The instrument will be able to operate in two operating modes: triple quadrupole and linear trap. This mass spectrometer has important performance features that distinguish it from other instruments available on campus and other instruments available on the market and will enable us to perform high-end experiments for small molecule quantitation. The QTRAP 7500 offers state-of-the-art technology for quantitation, identification, and structural analysis of small molecules. It will be used to solve challenging analytical problems and identify and quantify small molecules, such as lipids, hormones, and environmental contaminants and their metabolites related to disease. The instrument will initially support projects from twelve investigators with major research projects with NIH RO1 support and six investigators with minor research projects that require the sensitivity and high throughput ability of the QTRAP 7500 +mass spectrometer. The instrument will be housed in the Analytical Toxicology Core Laboratory in the Center for Environmental and Human Toxicology and will be available for service on a charge for service basis, with primary access for individuals with NIH support.