J M Patel

J M Patel, M.D., Ph.D.

PROFESSOR

Department: MD-PULMONARY MEDICINE
Business Phone: (352) 376-1611
Business Email: pateljm@medicine.ufl.edu

Research Profile

Development of a rat model of lung transplantation; Biology and toxicology of nitric oxide (NO); Regulation of lung endothelial cell NO synthase (eNOS); Pulmonary system toxicology of drugs and environmental chemicals; Role of Thioredoxin in Lung Allograft Inju

Publications

2016
Cell Penetrating Peptide-Mediated Caveolae-Dependent Activation of Lung Endothelial Nitric Oxide Synthase.
Protein and peptide letters. 23(2):169-75 [PMID] 26655728.
2015
Peptide-stimulated angiogenesis: Role of lung endothelial caveolar signaling and nitric oxide.
Nitric oxide : biology and chemistry. 51:43-51 [DOI] 10.1016/j.niox.2015.10.002. [PMID] 26537637.
2015
Thioredoxin priming prolongs lung allograft survival by promoting immune tolerance.
PloS one. 10(5) [DOI] 10.1371/journal.pone.0124705. [PMID] 25933390.
2014
Thioredoxin-1 Priming: a Novel Strategy To Induce Tolerance in a Rat Model of Lung Transplantation
Journal of Heart and Lung Transplantation. 33(4, S)
2013
Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.
American journal of respiratory and critical care medicine. 187(6):648-57 [DOI] 10.1164/rccm.201205-0880OC. [PMID] 23370913.
2012
Enhanced phosphorylation of caveolar PKC-α limits peptide internalization in lung endothelial cells.
Molecular and cellular biochemistry. 360(1-2):309-20 [DOI] 10.1007/s11010-011-1070-4. [PMID] 21948261.
2012
Hypoxia-induced endothelial CX3CL1 triggers lung smooth muscle cell phenotypic switching and proliferative expansion.
American journal of physiology. Lung cellular and molecular physiology. 303(10):L912-22 [DOI] 10.1152/ajplung.00014.2012. [PMID] 23002075.
2012
Novel peptide for attenuation of hypoxia-induced pulmonary hypertension via modulation of nitric oxide release and phosphodiesterase -5 activity.
Peptides. 35(1):78-85 [DOI] 10.1016/j.peptides.2012.03.009. [PMID] 22465621.
2010
A cellular model to mimic exhaled cigarette smokeinduced lung microvascular endothelial cell injury and death.
International journal of clinical and experimental medicine. 3(3):223-32 [PMID] 20827320.
2010
Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?
Medical hypotheses. 74(6):1069-74 [DOI] 10.1016/j.mehy.2009.12.023. [PMID] 20064695.
2010
Endothelial arginase II responds to pharmacological inhibition by elevation in protein level.
Molecular and cellular biochemistry. 343(1-2):211-6 [DOI] 10.1007/s11010-010-0515-5. [PMID] 20563744.
2010
Hypoxic upregulation of arginase II in human lung endothelial cells.
American journal of physiology. Cell physiology. 299(6):C1541-8 [DOI] 10.1152/ajpcell.00068.2010. [PMID] 20861464.
2010
Idh1 and Idh2 Mutation Studies in 1473 Patients With Chronic-, Fibrotic- Or Blast-Phase Essential Thrombocythemia, Polycythemia Vera Or Myelofibrosis
Leukemia. 24(7):1302-1309 [DOI] 10.1038/leu.2010.113. [PMID] 20508616.
2010
Role of the CX3CL1-CX3CR1 axis in chronic inflammatory lung diseases.
International journal of clinical and experimental medicine. 3(3):233-44 [PMID] 20827321.
2010
The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.
American journal of respiratory and critical care medicine. 182(8):1065-72 [DOI] 10.1164/rccm.200912-1840OC. [PMID] 20581171.
2009
Hypoxic upregulation of preproendothelin-1 gene expression is associated with protein tyrosine kinase-PI3K signaling in cultured lung vascular endothelial cells.
International journal of clinical and experimental medicine. 2(1):87-94 [PMID] 19436835.
2009
Nuclear Localization of Active Matrix Metalloproteinase-2 in Cigarette Smoke-Exposed Apoptotic Endothelial Cells
Experimental Lung Research. 35(1):59-75 [DOI] 10.1080/01902140802406059. [PMID] 19191105.
2009
Peptide-stimulation enhances compartmentalization and the catalytic activity of lung endothelial NOS.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 24(5-6):471-82 [DOI] 10.1159/000257487. [PMID] 19910687.
2008
Endothelial Alpha-1-Antitrypsin Attenuates Cigarette Smoke Induced Apoptosis in Vitro
Copd-Journal of Chronic Obstructive Pulmonary Disease. 5(3):153-162 [DOI] 10.1080/15412550802092936. [PMID] 18568839.
2008
Priming donor lungs with thioredoxin-1 attenuates acute allograft injury in a rat model of lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 27(10):1142-9 [DOI] 10.1016/j.healun.2008.07.006. [PMID] 18926407.
2008
Thioredoxin as a biomarker for graft rejection in lung transplant recipients.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 13(5):486-95 [PMID] 18979641.
2008
Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells.
American journal of physiology. Cell physiology. 295(5):C1183-90 [DOI] 10.1152/ajpcell.00075.2008. [PMID] 18784379.
2007
Nitric oxide upregulation of caspase-8 mRNA expression in lung endothelial cells: role of JAK2/STAT-1 signaling.
Molecular and cellular biochemistry. 305(1-2):71-7 [PMID] 17565448.
2006
A causal role for uric acid in fructose-induced metabolic syndrome.
American journal of physiology. Renal physiology. 290(3):F625-31 [PMID] 16234313.
2006
Peptides modified by myristoylation activate eNOS in endothelial cells through Akt phosphorylation.
British journal of pharmacology. 148(5):732-40 [PMID] 16715118.
2005
Angiotensin IV enhances phosphorylation of 4EBP1 by multiple signaling events in lung endothelial cells.
Molecular and cellular biochemistry. 275(1-2):181-8 [PMID] 16342424.
2005
Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial nitric oxide synthase.
American journal of respiratory cell and molecular biology. 33(5):513-20 [PMID] 16100081.
2005
Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells.
American journal of physiology. Cell physiology. 288(4):C840-9 [PMID] 15561762.
2004
Autoinhibitory domain fragment of endothelial NOS enhances pulmonary artery vasorelaxation by the NO-cGMP pathway.
American journal of physiology. Lung cellular and molecular physiology. 286(5):L1066-74 [PMID] 14729513.
2004
Nitric oxide-modulated marker gene expression of signal transduction pathways in lung endothelial cells.
Nitric oxide : biology and chemistry. 11(4):290-7 [PMID] 15604041.
2003
Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells.
Mechanisms of ageing and development. 124(8-9):911-9 [PMID] 14499496.
2003
Thioredoxin restores nitric oxide-induced inhibition of protein kinase C activity in lung endothelial cells.
Molecular and cellular biochemistry. 254(1-2):47-54 [PMID] 14674681.
2002
Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation.
American journal of physiology. Lung cellular and molecular physiology. 283(4):L707-16 [PMID] 12225947.
2002
Down-regulation of mitochondrial cytochrome c oxidase in senescent porcine pulmonary artery endothelial cells.
Mechanisms of ageing and development. 123(10):1363-74 [PMID] 12297339.
2002
Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells.
Mechanisms of ageing and development. 123(6):613-25 [PMID] 11850025.
2002
NO upregulation of a cyclic nucleotide-gated channel contributes to calcium elevation in endothelial cells.
American journal of physiology. Cell physiology. 283(4):C1080-9 [PMID] 12225972.
1999
Angiotensin II-stimulated nitric oxide release from porcine pulmonary endothelium is mediated by angiotensin IV.
Journal of the American Society of Nephrology. 10(3):481-91 [PMID] 10073598.
1999
Increased expression of calreticulin is linked to ANG IV-mediated activation of lung endothelial NOS.
American Journal of Physiology. 277(4 Pt 1):L794-801 [DOI] 10.1152/ajplung.1999.277.4.L794. [PMID] 10516221.
1998
Angiotensin IV receptor-mediated activation of lung endothelial NOS is associated with vasorelaxation
American Journal of Physiology. 275(6):L1061-8 [DOI] 10.1152/ajplung.1998.275.6.L1061. [PMID] 9843842.
1996
Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity.
American journal of respiratory cell and molecular biology. 15(3):410-9 [PMID] 8810647.
1995
Sulfhydryl-disulfide modulation and the role of disulfide oxidoreductases in regulation of the catalytic activity of nitric oxide synthase in pulmonary artery endothelial cells.
American journal of respiratory cell and molecular biology. 13(3):352-9 [PMID] 7544597.
1993
Acrolein-induced injury to cultured pulmonary artery endothelial cells.
Toxicology and applied pharmacology. 122(1):46-53 [PMID] 8397454.
1992
Oxidant and angiotensin II-induced subcellular translocation of protein kinase C in pulmonary artery endothelial cells.
Journal of biochemical toxicology. 7(2):117-23 [PMID] 1404242.
1991
Angiotensin receptor-mediated stimulation of diacylglycerol production in pulmonary artery endothelial cells
American Journal of Respiratory Cell and Molecular Biology. 5(4):321-7 [DOI] 10.1165/ajrcmb/5.4.321. [PMID] 1910816.
1991
Vitamin E distribution and modulation of the physical state and function of pulmonary endothelial cell membranes.
Experimental lung research. 17(4):707-23 [PMID] 1935832.
1990
Metabolism and pulmonary toxicity of cyclophosphamide.
Pharmacology & therapeutics. 47(1):137-46 [PMID] 2195554.
1990
Oxidant injury increases cell surface receptor binding of angiotensin II to pulmonary artery endothelial cells.
Journal of biochemical toxicology. 5(4):253-8 [PMID] 2096220.
1989
Angiotensin receptors in pulmonary arterial and aortic endothelial cells.
The American journal of physiology. 256(5 Pt 1):C987-93 [PMID] 2719100.
1988
Effect of nitrogen dioxide on surface membrane fluidity and insulin receptor binding of pulmonary endothelial cells.
Biochemical pharmacology. 37(8):1497-507 [PMID] 3358780.
1988
The effect of oxidant gases on membrane fluidity and function in pulmonary endothelial cells.
Free radical biology & medicine. 4(2):121-34 [PMID] 3278951.
1988
Vitamin E, membrane order, and antioxidant behavior in lung microsomes and reconstituted lipid vesicles.
Toxicology and applied pharmacology. 96(1):101-14 [PMID] 3188015.

Grants

May 2010 – Apr 2016
Angiotensin-Converting Enzyme2 in Vascular Endothelial Function
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI

Education

Ph.D. in Biochemistry
1973 · Marathwada University, Aurangabad
M.S. Master of Science in Biochemistry
1971 · Marathwada University, Aurangabad

Contact Details

Phones:
Business:
(352) 376-1611
Emails:
Addresses:
Business Mailing:
PO Box 100277
GAINESVILLE FL 32610
Business Street:
J277 JHMHC
GAINESVILLE FL 32611