Core Services

Human Health Risk Assessment

The RAC provides this service….

Environmental Risk Assessment

Exciting information concerning risk.

PK and PBPK Modeling

The Risk Assessment Core provides the following PK and PBPK analyses, including  (1) Non-compartmental pharmacokinetic analysis; (2) Compartmental pharmacokinetic modeling; (3) Population pharmacokinetic analysis using nonlinear mixed effects (NLME) modeling; (4) Physiologically based pharmacokinetic (PBPK) modeling; (5) Population physiologically based pharmacokinetic modeling using Monte Carlo simulations; (6) Bayesian population physiologically based pharmacokinetic modeling using Markov chain Monte Carlo simulations; (7) Pharmacokinetic-pharmacodynamic (PK/PD) modeling; and (8) Physiologically based pharmacokinetic-pharmacodynamic (PBPK/PD) modeling.