John A Bowden,

The research I am pursuing in my laboratory focuses on employing mass spectrometric methods at the chem/bio interface, with a long-standing interest in endocrine disruption and environmental chemistry. A new drive in the laboratory is focused on studying the interplay between external measures of exposure (e.g., anthropogenic contaminants) and internal measures of exposure (e.g., lipids, hormones), in the context of health and disease. The tools we use to study these relationships are either gas or liquid chromatography and mass spectrometry (employing both targeted and non-targeted workflows). Beyond the implementation of these workflows, a considerable effort in the laboratory also focuses on improving key metrological aspects, including method development and optimization, quantitation, and quality control. Current work primarily employs workflows capable of performing lipidomics, metabolomics, and the measurement of chemicals of emerging concern (e.g., perfluorinated chemicals). Application areas are varied, encompassing environmental sampling, nutritional studies, lab-based models, and both wildlife and human health.