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UF Health University of Florida

Center for Environmental & Human Toxicology

College of Veterinary Medicine

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Christopher Vulpe

Christopher Vulpe, MD, PhD

Professor

Department: Department of Physiological Sciences
Business Phone: (650) 291-5679
Business Email: cvulpe@ufl.edu

Publications

2020
CXL146, a novel 4H-chromene derivative, targets GRP78 to selectively eliminate multidrug resistant cancer cells
Molecular Pharmacology
2020
Functional Pathway Identification with CRISPR/Cas9 Genome Wide Gene Disruption in Human Dopaminergic Neuronal Cells Following Chronic Treatment with Dieldrin
Toxicological Sciences
2019
Biallelic HEPHL1 variants impair ferroxidase activity and cause an abnormal hair phenotype
Plos Genetics
2019
Crumpling of silver nanowires by endolysosomes strongly reduces toxicity
Proceedings of the National Academy of Sciences of the United States of America. Biological Sciences
2019
Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes
Scientific Reports
2019
Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition
Cell Host & Microbe
2019
Propagation of functional estrogen receptor positive normal human breast cells in 3D cultures
Breast cancer research and treatment.
2018
Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.
Redox Biology
2018
Ctcf Boundary Remodels Chromatin Domain and Drives Aberrant Hox Gene Transcription in Acute Myeloid Leukemia
Blood
2018
Multi-Copper Ferroxidase-Deficient Mice Have Increased Brain Iron Concentrations and Learning and Memory Deficits
The Journal of nutrition
2018
Multiple environmental stressors induce complex transcriptomic responses indicative of phenotypic outcomes in Western fence lizard
Bmc Genomics
2018
The Toxicogenome of Hyalella Azteca: a Model for Sediment Ecotoxicology and Evolutionary Toxicology
2018
Transcriptomic and Network Analyses Reveal Mechanistic-Based Biomarkers of Endocrine Disruption in the Marine Mussel, Mytilus edulis.
Environmental Science & Technology
2017
Hamp1 Mrna and Plasma Hepcidin Levels Are Influenced By Sex and Strain But Do Not Predict Tissue Iron Levels in Inbred Mice
American Journal of Physiology-Gastrointestinal and Liver Physiology
2017
How Consistent Are We? Interlaboratory Comparison Study in Fathead Minnows Using the Model Estrogen 17 Alpha-Ethinylestradiol to Develop Recommendations for Environmental Transcriptomics
Environmental Toxicology
2017
Intestinal Hephaestin Potentiates Iron Absorption in Weanling, Adult, and Pregnant Mice Under Physiological Conditions
2017
Nicotinamide N-methyltransferase expression decreases in iron overload, exacerbating toxicity in mouse hepatocytes
Hepatology Communications
2017
Design and Testing of Safer, More Effective Preservatives for Consumer Products
ACS Sustainable Chemistry & Engineering
2016
Hephaestin and Ceruloplasmin Facilitate Iron Metabolism in the Mouse Kidney
Scientific Reports
2014
Gene Networks and Toxicity Pathways Induced By Acute Cadmium Exposure in Adult Largemouth Bass (Micropterus Salmoides)
2014
Molecular Signature and Dna Damage Pathways Altered in Male Largemouth Bass (Micropterus Salmoides) By a Single Dose of Benzene and Trichloroethylene
Environmental and Molecular Mutagenesis
2013
A Genome-Wide Screen Identifies Yeast Genes Required for Tolerance To Technical Toxaphene, An Organochlorinated Pesticide Mixture
PLoS One
2013
Cytosolic Ferroxidase (Cytofox) Activity in Rodent Enterocytes Is Independent of Ceruloplasmin and Amyloid Precursor Protein
American Journal of Hematology
2013
Functional Profiling Discovers the Dieldrin Organochlorinated Pesticide Affects Leucine Availability in Yeast
Toxicological Sciences

Grants

Jul 2019 ACTIVE
Role of Bcl11b in CD4+ T cells and innate lymphoid cells
NATL INST OF HLTH NIAID ·
Jul 2019 ACTIVE
Together: Transforming and Translating Discovery to Improve Health
NATL INST OF HLTH NCATS · Project Manager
Jun 2018 ACTIVE
OR-DRPD-ROD2018: Development of Leukemia-Oncotype Prototype CARS (Cytarabine AML Response Score) for Prediction of Relapse Risk in AML
UF RESEARCH · Project Manager
Sep 2017 ACTIVE
UFHCC Triple Negative Breast Cancer (TNBC) Pilot Project Program
MULTIPLE SPONSORS · Project Manager
Jun 2017 – Apr 2018
CRISPR-CAS9 Genomic Screening COR
US ENVIRONMENTAL PRO AGCY · Principal Investigator
Apr 2017 ACTIVE
OoR CTSI Institutional Matching Support
UF DIV OF SPONSORED RES MATCHING FUNDS · Project Manager
Mar 2017 – Mar 2018
Improved in vitro metabolism in HepG2 cells using CRISPRa Technology
JOHNS HOPKINS UNIV · Principal Investigator
Sep 2016 ACTIVE
Southeastern and Coastal Center for Agricultural Health and Safety (SCC-AHS)
CTRS FOR DIS CNTRL INST OCCUP SFTY HLTH · Project Manager
Sep 2016 ACTIVE
Nanowire Intelligent Re-design and Recycling for Environmental Safety
CONSUMER PRODUCT SAFETY COMM · Principal Investigator
Aug 2016 – Feb 2020
Environmental and Genetic Determinants of Transitional Cell Carcinoma of the Urinary Tract in Scottish Terriers funded by Olive's Way
UF FOU ·
Jul 2016 – Jul 2017
Transform Tox Testing Challenge: Innovating for Metaboli
US ENVIRONMENTAL PRO AGCY · Principal Investigator
Jun 2016 – May 2018
Functional screening to identify mediators of dopaminerg
UF DSR OPPORTUNITY FUND · Principal Investigator
Nov 2015 – Dec 2016
Genomic Differences in response of daphnia magna
INTL COPPER ASSOC · Principal Investigator
Sep 2015 – Jun 2018
High throughput transcriptional profiling of human mammary stem cell denived organoids
LAWRENCE BERKELEY NATL LAB · Principal Investigator
Jun 2015 – May 2018
An Integrated molecular approach to understand
NATL INST OF HLTH NIGMS · Principal Investigator
May 2015 – Apr 2019
Functional Profiling to Identify Mitochondria-cell
NATL INST OF HLTH NIEHS · Principal Investigator
Jan 2015 ACTIVE
Investigating Biogeochenical Controls on Metal Toxicity Using Stable Isotopes
COLORADO SCHOOL OF MINES · Principal Investigator

Education

M.D., Medicine
1996 · University of California
Ph.D., Biochemistry, Genetics
1994 · University of California
S.B., Biology
1986 · Massachusetts Institute of Technology

Contact Details

Phones:
Business:
(650) 291-5679
Emails:
Business:
cvulpe@ufl.edu
Addresses:
Mailing:
PO Box 100144
 GAINESVILLE FL 32610